非酒精性脂肪肝疾病纖維化分數 NAFLD fibrosis score (NFS)
= -1.675 + (0.037*age [years]) + (0.094*BMI [kg/m2]) + (1.13*IFG/diabetes [yes = 1, no = 0]) +
(0.99*AST/ALT ratio) – (0.013*Platelet [X109/L]) – (0.66*Albumin [g/dl])
|
納入Rule-in |
排除Rule-out |
檢測具有嚴重肝纖維化 Assessment of Advanced fibrosis* |
≥0.672 |
<-1.44 |
*不適用於年齡小於35歲以及高風險族群(糖尿病、肥胖等)。 Not accurate in age <35 y, people with obesity and/or type 2 diabetes.
*空腹血糖偏高 (IFG) 定義為空腹血糖指數(FPG) 數值介於 110–125 mg/dL. Impaired fasting glucose (IFG) defined as a fasting plasma glucose(FPG) level of 110–125 mg/dL.:
參考文獻References:
- Mellitus, D. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997, 20, 1183–1197.
- McPherson, Stuart, et al. "Age as a confounding factor for the accurate non-invasive diagnosis of advanced NAFLD fibrosis." The American journal of gastroenterology 112.5 (2017): 740.
- Barb, Diana, et al. "Type 2 diabetes mellitus increases the risk of hepatic fibrosis in individuals with obesity and nonalcoholic fatty liver disease." Obesity 29.11 (2021): 1950-1960.
- Graupera, Isabel, et al. "Low accuracy of FIB-4 and NAFLD fibrosis scores for screening for liver fibrosis in the population." Clinical Gastroenterology and Hepatology 20.11 (2022): 2567-2576.